Proteomic insights into parasite biology.

نویسندگان

  • Michael L Ginger
  • Paul G McKean
  • Richard Burchmore
  • Karen M Grant
چکیده

MICHAEL L. GINGER, PAUL G. MCKEAN, RICHARD BURCHMORE and KAREN M. GRANT Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster University, LA1 4YK, UK Faculty of Health and Medicine, Lancaster Medical School, Lancaster University, LA1 4YA, UK Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ, UK

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A proteomic analysis of malaria biology: integration of old literature and new technologies.

The genomic revolution has brought a new vitality into research on Plasmodium, its insect and vertebrate hosts. At the cellular level nowhere is the impact greater than in the analysis of protein expression and the 'assembly' of the supramolecular machines that together comprise the functional cell. The repetitive phases of invasion and replication that typify the malaria life cycle, together w...

متن کامل

Subcellular Proteomics and Global Analysis of Posttranslational Modifica- tions to Study Functional Roles of Trypanosoma cruzi Molecules

One century after the discovery of Chagas disease, the treatment for this illness is still based only on two drugs with limited efficacy and severe side effects. In this mini-review, we discuss the application of mass spectrometry (MS)based proteomic approaches to study the biochemistry and cell biology of etiologic agent of Chagas disease, Trypanosoma cruzi. We focus the discussion in the anal...

متن کامل

The Transcriptome of Trichuris suis – First Molecular Insights into a Parasite with Curative Properties for Key Immune Diseases of Humans

BACKGROUND Iatrogenic infection of humans with Trichuris suis (a parasitic nematode of swine) is being evaluated or promoted as a biological, curative treatment of immune diseases, such as inflammatory bowel disease (IBD) and ulcerative colitis, in humans. Although it is understood that short-term T. suis infection in people with such diseases usually induces a modified Th2-immune response, not...

متن کامل

ژنومیکس انگل ها

Genes carry instructions to make protein that affect body's cells and their physical activity. They also play an important role in the occurrence of various characteristics in the body. Recently, scientists in the new field of science known as genomics have studied the genetic instructions. Genomics deals with the discovery of all the sequences in the entire genome of organisms and is used to s...

متن کامل

New Perspectives on Host-Parasite Interplay by Comparative Transcriptomic and Proteomic Analyses of Schistosoma japonicum

Schistosomiasis remains a serious public health problem with an estimated 200 million people infected in 76 countries. Here we isolated ~ 8,400 potential protein-encoding cDNA contigs from Schistosoma japonicum after sequencing circa 84,000 expressed sequence tags. In tandem, we undertook a high-throughput proteomics approach to characterize the protein expression profiles of a number of develo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Parasitology

دوره 139 9  شماره 

صفحات  -

تاریخ انتشار 2012